Determination of Rate Constants and Equilibrium Constants for Solution-Phase Drug–Protein Interactions by Ultrafast Affinity Extraction

[Image: see text] A method was created on the basis of ultrafast affinity extraction to determine both the dissociation rate constants and equilibrium constants for drug–protein interactions in solution. Human serum albumin (HSA), an important binding agent for many drugs in blood, was used as both...

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Detalles Bibliográficos
Autores principales: Zheng, Xiwei, Li, Zhao, Podariu, Maria I., Hage, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082384/
https://www.ncbi.nlm.nih.gov/pubmed/24911267
http://dx.doi.org/10.1021/ac501031y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082384/
https://www.ncbi.nlm.nih.gov/pubmed/24911267
http://dx.doi.org/10.1021/ac501031y

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