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Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines

The use of DNA to deliver vaccine antigens offers many advantages, including ease of manufacture and cost. However, most DNA vaccines are plasmids and must be grown in bacterial culture, necessitating elements which are either unnecessary for effective gene delivery (e.g. bacterial origins of replic...

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Detalles Bibliográficos
Autores principales: Walters, Adam A., Kinnear, Ekaterina, Shattock, Robin J., McDonald, Jacqueline U., Caproni, Lisa J., Porter, Neil, Tregoning, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082409/
https://www.ncbi.nlm.nih.gov/pubmed/24830436
http://dx.doi.org/10.1038/gt.2014.37