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A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression
R loops are three-stranded nucleic acid structures that comprise nascent RNA hybridized with the DNA template, leaving the nontemplate DNA single-stranded. R loops form naturally during transcription even though their persistent formation can be a risky outcome with deleterious effects on genome int...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083084/ https://www.ncbi.nlm.nih.gov/pubmed/24990962 http://dx.doi.org/10.1101/gad.242990.114 |