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Feature-based multiple models improve classification of mutation-induced stability changes

BACKGROUND: Reliable prediction of stability changes in protein variants is an important aspect of computational protein design. A number of machine learning methods that allow a classification of stability changes knowing only the sequence of the protein emerged. However, their performance on amino...

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Detalles Bibliográficos
Autores principales: Folkman, Lukas, Stantic, Bela, Sattar, Abdul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083411/
https://www.ncbi.nlm.nih.gov/pubmed/25057118
http://dx.doi.org/10.1186/1471-2164-15-S4-S6