NeEMO: a method using residue interaction networks to improve prediction of protein stability upon mutation

BACKGROUND: The rapid growth of un-annotated missense variants poses challenges requiring novel strategies for their interpretation. From the thermodynamic point of view, amino acid changes can lead to a change in the internal energy of a protein and induce structural rearrangements. This is of grea...

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Detalles Bibliográficos
Autores principales: Giollo, Manuel, Martin, Alberto JM, Walsh, Ian, Ferrari, Carlo, Tosatto, Silvio CE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083412/
https://www.ncbi.nlm.nih.gov/pubmed/25057121
http://dx.doi.org/10.1186/1471-2164-15-S4-S7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083412/
https://www.ncbi.nlm.nih.gov/pubmed/25057121
http://dx.doi.org/10.1186/1471-2164-15-S4-S7

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