Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which...

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Detalles Bibliográficos
Autores principales: Xu, Yingqi, Plechanovová, Anna, Simpson, Peter, Marchant, Jan, Leidecker, Orsolya, Kraatz, Sebastian, Hay, Ronald T., Matthews, Steve J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083429/
https://www.ncbi.nlm.nih.gov/pubmed/24969970
http://dx.doi.org/10.1038/ncomms5217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083429/
https://www.ncbi.nlm.nih.gov/pubmed/24969970
http://dx.doi.org/10.1038/ncomms5217

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