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Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which...

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Detalles Bibliográficos
Autores principales:	Xu, Yingqi, Plechanovová, Anna, Simpson, Peter, Marchant, Jan, Leidecker, Orsolya, Kraatz, Sebastian, Hay, Ronald T., Matthews, Steve J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083429/ https://www.ncbi.nlm.nih.gov/pubmed/24969970 http://dx.doi.org/10.1038/ncomms5217

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