Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca(2+) channel activators

Cav1.2 and Cav1.3 are the main L-type Ca(2+) channel subtypes in the brain. Cav1.3 channels have recently been implicated in the pathogenesis of Parkinson’s disease. Therefore, Cav1.3-selective blockers are developed as promising neuroprotective drugs. We studied the pharmacological properties of a...

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Detalles Bibliográficos
Autores principales: Ortner, Nadine J., Bock, Gabriella, Vandael, David H.F., Mauersberger, Robert, Draheim, Henning J., Gust, Ronald, Carbone, Emilio, Tuluc, Petronel, Striessnig, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083433/
https://www.ncbi.nlm.nih.gov/pubmed/24941892
http://dx.doi.org/10.1038/ncomms4897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083433/
https://www.ncbi.nlm.nih.gov/pubmed/24941892
http://dx.doi.org/10.1038/ncomms4897

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