Cargando…

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca(2+) channel activators

Cav1.2 and Cav1.3 are the main L-type Ca(2+) channel subtypes in the brain. Cav1.3 channels have recently been implicated in the pathogenesis of Parkinson’s disease. Therefore, Cav1.3-selective blockers are developed as promising neuroprotective drugs. We studied the pharmacological properties of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ortner, Nadine J., Bock, Gabriella, Vandael, David H.F., Mauersberger, Robert, Draheim, Henning J., Gust, Ronald, Carbone, Emilio, Tuluc, Petronel, Striessnig, Jörg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083433/ https://www.ncbi.nlm.nih.gov/pubmed/24941892 http://dx.doi.org/10.1038/ncomms4897

Ejemplares similares

Investigation of the Selectivity of L-Type Voltage-Gated Calcium Channels 1.3 for Pyrimidine-2,4,6-Triones Derivatives Based on Molecular Dynamics Simulation
por: Ye, Qi, et al.
Publicado: (2020)

Syntheses of Radioiodinated Pyrimidine-2,4,6-Triones as Potential Agents for Non-Invasive Imaging of Matrix Metalloproteinases
por: Breyholz, Hans-Jörg, et al.
Publicado: (2017)

How and why are calcium currents curtailed in the skeletal muscle voltage‐gated calcium channels?
por: Flucher, Bernhard E., et al.
Publicado: (2017)

L-type Ca(2+) channels in heart and brain
por: Striessnig, Jörg, et al.
Publicado: (2014)

Gating defects of disease-causing de novo mutations in Ca(v)1.3 Ca(2+) channels
por: Pinggera, Alexandra, et al.
Publicado: (2018)

1,3-Dimethyl-5-(2-methylbenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
por: Panchatcharam, R., et al.
Publicado: (2009)

Role of High Voltage-Gated Ca(2+) Channel Subunits in Pancreatic β-Cell Insulin Release. From Structure to Function
por: Tuluc, Petronel, et al.
Publicado: (2021)

Stabilization of negative activation voltages of Cav1.3 L-Type Ca(2+)-channels by alternative splicing
por: Hofer, Nadja T., et al.
Publicado: (2020)

Structural determinants of voltage-gating properties in calcium channels
por: Fernández-Quintero, Monica L, et al.
Publicado: (2021)

C-Terminal Modulatory Domain Controls Coupling of Voltage-Sensing to Pore Opening in Ca(v)1.3 L-type Ca(2+) Channels
por: Lieb, Andreas, et al.
Publicado: (2014)

Calcium current modulation by the γ(1) subunit depends on alternative splicing of Ca(V)1.1
por: El Ghaleb, Yousra, et al.
Publicado: (2022)

Crystal structure of 5,5-bis(4-methylbenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione monohydrate
por: Ravi Kiran, Bhaskarachar, et al.
Publicado: (2015)

Voltage-Gated Ca(2+) Channels in Dopaminergic Substantia Nigra Neurons: Therapeutic Targets for Neuroprotection in Parkinson's Disease?
por: Ortner, Nadine J.
Publicado: (2021)

5-[1-(1,3-Dimethyl-2,4,6-trioxohexahydropyrimidin-5-yl)-2-oxopropyl]-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
por: Sweidan, Kamal, et al.
Publicado: (2013)

Role of putative voltage-sensor countercharge D4 in regulating gating properties of Ca(V)1.2 and Ca(V)1.3 calcium channels
por: Costé de Bagneaux, Pierre, et al.
Publicado: (2018)

Voltage‐gated calcium channels – from basic mechanisms to disease
por: Striessnig, Jörg
Publicado: (2016)

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated Ca(V)1.2 Calcium Channel Function
por: Kaur, Gurjot, et al.
Publicado: (2015)

Mechanisms Responsible for ω-Pore Currents in Ca(v) Calcium Channel Voltage-Sensing Domains
por: Monteleone, Stefania, et al.
Publicado: (2017)

Rubidium 2,4,6-trioxo-1,3-diazinan-5-ide–1,3-diazinane-2,4,6-trione–water (1/1/1)
por: Gryl, Marlena, et al.
Publicado: (2011)

The human channel gating–modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome–like phenotype in mice
por: Ortner, Nadine J., et al.
Publicado: (2023)

Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder
por: Hofer, Nadja T., et al.
Publicado: (2020)

STAC proteins associate to the IQ domain of Ca(V)1.2 and inhibit calcium-dependent inactivation
por: Campiglio, Marta, et al.
Publicado: (2018)

Voltage-Gated Ca(2+)-Channel α1-Subunit de novo Missense Mutations: Gain or Loss of Function – Implications for Potential Therapies
por: Striessnig, Jörg
Publicado: (2021)

Ion-pair interactions between voltage-sensing domain IV and pore domain I regulate Ca(V)1.1 gating
por: El Ghaleb, Yousra, et al.
Publicado: (2021)

Crystal structure of 5-[bis(methylsulfonyl)methyl]-1,3-dimethyl-5-(methylsulfonyl)pyrimidine-2,4,6(1H,3H,5H)-trione
por: Mallah, Eyad, et al.
Publicado: (2015)

5-(3,4-Dimethoxybenzylidene)-1,3-dimethyl-1,3-diazinane-2,4,6-trione
por: Gohain, Mukut, et al.
Publicado: (2011)

1,3,5-Tris(4-methoxyphenyl)-1,3,5-triazinane-2,4,6-trione
por: Fang, Li, et al.
Publicado: (2014)

Synthesis of 2,4,6-Tris(4-N-isopropylamidinophenyl)pyrimidine trihydrochloride
por: Bajić, Miroslav, et al.
Publicado: (2001)

Role of voltage gated Ca(2+) channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid
por: Qian, Aihua, et al.
Publicado: (2013)

Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in Ca(V)1.1 calcium channels
por: Tuluc, Petronel, et al.
Publicado: (2016)

(E)-5-[1-Hydroxy-3-(3,4,5-trimethoxyphenyl)allylidene]-1,3-dimethylpyrimidine-2,4,6-trione: crystal structure and Hirshfeld surface analysis
por: Soto-Monsalve, Mónica, et al.
Publicado: (2017)

L-type calcium channels as drug targets in CNS disorders
por: Ortner, Nadine J, et al.
Publicado: (2015)

Channelopathies in Ca(v)1.1, Ca(v)1.3, and Ca(v)1.4 voltage-gated L-type Ca(2+) channels
por: Striessnig, Jörg, et al.
Publicado: (2010)

Bis(2,4,6-triaminopyrimidin-1-ium) sulfate pentahydrate
por: Nimthong, Ruthairat, et al.
Publicado: (2013)

De novo CACAN1D Ca(2+) channelopathies: clinical phenotypes and molecular mechanism
por: Ortner, Nadine J., et al.
Publicado: (2020)

Long tailed trions in monolayer MoS(2): Temperature dependent asymmetry and resulting red-shift of trion photoluminescence spectra
por: Christopher, Jason W., et al.
Publicado: (2017)

Synthesis and PASS-assisted in silico approach of some novel 2-substituted benzimidazole bearing a pyrimidine-2, 4, 6(trione) system as mucomembranous protector
por: Mathew, Bijo, et al.
Publicado: (2013)

Perhalogenated pyrimidine scaffolds. Reactions of 5-chloro-2,4,6-trifluoropyrimidine with nitrogen centred nucleophiles
por: Parks, Emma L, et al.
Publicado: (2008)

Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?
por: Striessnig, Jörg, et al.
Publicado: (2015)

Exciting leak: Na(+) background current makes chromaffin cells burst
por: Tuluc, Petronel
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qcqh9fkksjuf8mmsb7lb2qhi97