Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool

Germline or B-cell-specific loss of Ptpn6 gene encoding the Shp1 protein tyrosine phosphatase leads to skewed B lymphopoiesis and systemic autoimmunity. Here, to study its role in B-cell terminal differentiation, we generated Ptpn6(f/f)Aicda(Cre/+) mice with Shp1 ablated only in activated B cells. W...

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Detalles Bibliográficos
Autores principales: Li, Yan-Feng, Xu, Shengli, Ou, Xijun, Lam, Kong-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083441/
https://www.ncbi.nlm.nih.gov/pubmed/24978161
http://dx.doi.org/10.1038/ncomms5273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083441/
https://www.ncbi.nlm.nih.gov/pubmed/24978161
http://dx.doi.org/10.1038/ncomms5273

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