The Targeted Transduction of MMP-Overexpressing Tumor Cells by ACPP-HPMA Copolymer-Coated Adenovirus Conjugates

We have designed and tested a new way to selectively deliver HPMA polymer-coated adenovirus type 5 (Ad5) particles into matrix metalloproteinase (MMP)-overexpressing tumor cells. An activatable cell penetrating peptide (ACPP) was designed and attached to the reactive 4-nitrophenoxy groups of HPMA po...

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Detalles Bibliográficos
Autores principales: Li, Shuhua, Chen, Juanzhi, Xu, Huiyong, Long, Jie, Xie, Xiaobin, Zhang, Yajie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085062/
https://www.ncbi.nlm.nih.gov/pubmed/25000246
http://dx.doi.org/10.1371/journal.pone.0100670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085062/
https://www.ncbi.nlm.nih.gov/pubmed/25000246
http://dx.doi.org/10.1371/journal.pone.0100670

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