Cargando…

The Targeted Transduction of MMP-Overexpressing Tumor Cells by ACPP-HPMA Copolymer-Coated Adenovirus Conjugates

We have designed and tested a new way to selectively deliver HPMA polymer-coated adenovirus type 5 (Ad5) particles into matrix metalloproteinase (MMP)-overexpressing tumor cells. An activatable cell penetrating peptide (ACPP) was designed and attached to the reactive 4-nitrophenoxy groups of HPMA po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shuhua, Chen, Juanzhi, Xu, Huiyong, Long, Jie, Xie, Xiaobin, Zhang, Yajie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085062/ https://www.ncbi.nlm.nih.gov/pubmed/25000246 http://dx.doi.org/10.1371/journal.pone.0100670

Ejemplares similares

Traceless Bioresponsive Shielding of Adenovirus Hexon with HPMA Copolymers Maintains Transduction Capacity In Vitro and In Vivo
por: Prill, Jan-Michael, et al.
Publicado: (2014)

Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis
por: Wang, Dong, et al.
Publicado: (2007)

HPMA Copolymer Mebendazole Conjugate Allows Systemic Administration and Possesses Antitumour Activity In Vivo
por: Studenovský, Martin, et al.
Publicado: (2022)

HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer Cells
por: Peng, Zheng-Hong, et al.
Publicado: (2014)

HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery
por: Chytil, Petr, et al.
Publicado: (2021)

N-(2-hydroxypropyl)methacrylamide–amphotericin B (HPMA–AmB) copolymer conjugates as antileishmanial agents
por: Nicoletti, Salvatore, et al.
Publicado: (2009)

Combination Chemotherapy and Photodynamic Therapy with Fab′ Fragment Targeted HPMA Copolymer Conjugates in Human Ovarian Carcinoma Cells
por: Hongrapipat, Jarunee, et al.
Publicado: (2008)

Effect of Tumor Targeted-Anthracycline Nanomedicine, HPMA Copolymer-Conjugated Pirarubicin (P-THP) against Gynecological Malignancies
por: Yanazume, Shintaro, et al.
Publicado: (2022)

Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3
por: Bojarová, P., et al.
Publicado: (2018)

Mitochondria-Targeted Delivery of Camptothecin Based on HPMA Copolymer for Metastasis Suppression
por: Yi, Xiaoli, et al.
Publicado: (2022)

Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats
por: Cheah, Hoay Yan, et al.
Publicado: (2017)

Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers
por: Bertuzzi, Sara, et al.
Publicado: (2021)

Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels
por: Staley, Lyndsay A., et al.
Publicado: (2016)

HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy
por: Tavares, Marina R., et al.
Publicado: (2021)

PLL–Poly(HPMA) Bottlebrush-Based Antifouling Coatings: Three Grafting Routes
por: Roeven, Esther, et al.
Publicado: (2020)

Intratumoral Distribution and pH-Dependent Drug Release of High Molecular Weight HPMA Copolymer Drug Conjugates Strongly Depend on Specific Tumor Substructure and Microenvironment
por: Noack, Anne-Kathrin, et al.
Publicado: (2020)

Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging
por: Eppard, Elisabeth, et al.
Publicado: (2018)

HPMA-Based Polymer Conjugates for Repurposed Drug Mebendazole and Other Imidazole-Based Therapeutics
por: Studenovský, Martin, et al.
Publicado: (2021)

Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics
por: Bresseleers, Jaleesa, et al.
Publicado: (2020)

Synthesis, Morphology, and Rheological Evaluation of HPMA (N-2-Hydroxypropyl Methacrylamide)-PCL (Polycaprolactone) Conjugates
por: Rani, Sarita, et al.
Publicado: (2021)

Dual-Function Polymeric HPMA Prodrugs for the Delivery of miRNA
por: Peng, Zheng-Hong, et al.
Publicado: (2017)

292. Phosphorodiamidate Morpholino Oligomers Targeting acpP Reduce the Biofilm Burden in Burkholderia cepacia Complex
por: Mendez, Antonio R, et al.
Publicado: (2023)

Only Acyl Carrier Protein 1 (AcpP1) Functions in Pseudomonas aeruginosa Fatty Acid Synthesis
por: Ma, Jin-Cheng, et al.
Publicado: (2017)

Scale-Up of the Manufacturing Process To Produce Docetaxel-Loaded mPEG-b-p(HPMA-Bz) Block Copolymer Micelles for Pharmaceutical Applications
por: Bresseleers, Jaleesa, et al.
Publicado: (2019)

HPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation
por: Kramer, Stefan, et al.
Publicado: (2019)

Of its five acyl carrier proteins, only AcpP1 functions in Ralstonia solanacearum fatty acid synthesis
por: Yin, Yu, et al.
Publicado: (2022)

In Vitro and In Vivo Studies on HPMA-Based Polymeric Micelles Loaded with Curcumin
por: Bagheri, Mahsa, et al.
Publicado: (2021)

Targeting of the Essential acpP, ftsZ, and rne Genes in Carbapenem-Resistant Acinetobacter baumannii by Antisense PNA Precision Antibacterials
por: Nejad, Alireza Japoni, et al.
Publicado: (2021)

Structure-to-Efficacy Relationship of HPMA-Based Nanomedicines: The Tumor Spheroid Penetration Study
por: Kudláčová, Júlia, et al.
Publicado: (2020)

Antibody-pHPMA functionalised fluorescent silica nanoparticles for colorectal carcinoma targeting
por: Lizoňová, Denisa, et al.
Publicado: (2018)

Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice
por: Iizuka, Shunsuke, et al.
Publicado: (2015)

Protective Effect of Rifampicin Loaded by HPMA-PLA Nanopolymer on Macrophages Infected with Mycobacterium Tuberculosis
por: Yang, Guoping, et al.
Publicado: (2022)

Influence of drug and polymer molecular weight on release kinetics from HEMA and HPMA hydrogels
por: Toews, Parker, et al.
Publicado: (2023)

Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer
por: Nair, Renjith Parameswaran, et al.
Publicado: (2019)

Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia
por: Gündel, Daniel, et al.
Publicado: (2017)

Development of an ELISA for Measurement of Urinary 3-Hydroxypropyl Mercapturic Acid (3-HPMA), the Marker of Stroke
por: Sakamoto, Akihiko, et al.
Publicado: (2020)

Retracted: Protective Effect of Rifampicin Loaded by HPMA-PLA Nanopolymer on Macrophages Infected with Mycobacterium Tuberculosis
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Regulation of synovial cell function by adenovirus vector-mediated gene transduction
por: Tanaka, S, et al.
Publicado: (2003)

Enhanced Transduction and Replication of RGD-Fiber Modified Adenovirus in Primary T Cells
por: Sengupta, Sadhak, et al.
Publicado: (2011)

Adenovirus Co-Opts Neutrophilic Inflammation to Enhance Transduction of Epithelial Cells
por: Readler, James M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t2nv11g1saim5ktdgort48d4rj