The Kinesin-4 Protein KIF7 Regulates Mammalian Hedgehog Signaling by Organizing the Cilia Tip Compartment

Mammalian Hedgehog (Hh) signal transduction requires the primary cilium, a microtubule-based organelle, and the Gli/Sufu complexes that mediate Hh signaling are enriched at cilia tips. KIF7, a kinesin-4 family protein, is a conserved regulator of the Hh signaling pathway and a human ciliopathy prote...

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Detalles Bibliográficos
Autores principales: He, Mu, Subramanian, Radhika, Bangs, Fiona, Omelchenko, Tatiana, Liem, Karel F., Kapoor, Tarun M., Anderson, Kathryn V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085576/
https://www.ncbi.nlm.nih.gov/pubmed/24952464
http://dx.doi.org/10.1038/ncb2988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085576/
https://www.ncbi.nlm.nih.gov/pubmed/24952464
http://dx.doi.org/10.1038/ncb2988

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