DNA breaks and chromosomal aberrations arise when replication meets base excision repair

Exposures that methylate DNA potently induce DNA double-strand breaks (DSBs) and chromosomal aberrations, which are thought to arise when damaged bases block DNA replication. Here, we demonstrate that DNA methylation damage causes DSB formation when replication interferes with base excision repair (...

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Detalles Bibliográficos
Autores principales: Ensminger, Michael, Iloff, Lucie, Ebel, Christian, Nikolova, Teodora, Kaina, Bernd, Lӧbrich, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085701/
https://www.ncbi.nlm.nih.gov/pubmed/24982429
http://dx.doi.org/10.1083/jcb.201312078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085701/
https://www.ncbi.nlm.nih.gov/pubmed/24982429
http://dx.doi.org/10.1083/jcb.201312078

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