Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery

Diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) is one of the mammalian PPIP5K isoforms responsible for synthesis of diphosphoinositol polyphosphates (inositol pyrophosphates; PP-InsPs), regulatory molecules that function at the interface of cell signaling and organismic homeostasis. The deve...

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Detalles Bibliográficos
Autores principales: Wang, Huanchen, Godage, Himali Y., Riley, Andrew M., Weaver, Jeremy D., Shears, Stephen B., Potter, Barry V.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085797/
https://www.ncbi.nlm.nih.gov/pubmed/24768307
http://dx.doi.org/10.1016/j.chembiol.2014.03.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085797/
https://www.ncbi.nlm.nih.gov/pubmed/24768307
http://dx.doi.org/10.1016/j.chembiol.2014.03.009

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