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PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data

Interactions among transcriptional factors (TFs), cofactors and other proteins or enzymes can affect transcriptional regulatory capabilities of eukaryotic organisms. Post-translational modifications (PTMs) cooperate with TFs and epigenetic alterations to constitute a hierarchical complexity in trans...

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Detalles Bibliográficos
Autores principales: Guan, Daogang, Shao, Jiaofang, Zhao, Zhongying, Wang, Panwen, Qin, Jing, Deng, Youping, Boheler, Kenneth R., Wang, Junwen, Yan, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086064/
https://www.ncbi.nlm.nih.gov/pubmed/24875471
http://dx.doi.org/10.1093/nar/gku471