Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A

BACKGROUND: The neuronal cytoplasmic localization of SET, an inhibitor of the phosphatase 2A (PP2A), results in tau hyperphosphorylation in the brains of Alzheimer patients through mechanisms that are still not well defined. RESULTS: We used primary neurons and mouse brain slices to show that SET is...

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Detalles Bibliográficos
Autores principales: Chasseigneaux, Stéphanie, Clamagirand, Christine, Huguet, Léa, Gorisse-Hussonnois, Lucie, Rose, Christiane, Allinquant, Bernadette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086270/
https://www.ncbi.nlm.nih.gov/pubmed/24981783
http://dx.doi.org/10.1186/1471-2202-15-82

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086270/
https://www.ncbi.nlm.nih.gov/pubmed/24981783
http://dx.doi.org/10.1186/1471-2202-15-82

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