Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes

The present study shows low circulating levels of SIRT4 in obese patients with nonalcoholic fatty liver disease mirroring its reduced mitochondrial expression in an attempt to increase the fat oxidative capacity and then the mitochondrial function in liver and in muscle. SIRT4 modulates the metaboli...

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Autores principales: Tarantino, Giovanni, Finelli, Carmine, Scopacasa, Franco, Pasanisi, Fabrizio, Contaldo, Franco, Capone, Domenico, Savastano, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086623/
https://www.ncbi.nlm.nih.gov/pubmed/25045415
http://dx.doi.org/10.1155/2014/920676
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author Tarantino, Giovanni
Finelli, Carmine
Scopacasa, Franco
Pasanisi, Fabrizio
Contaldo, Franco
Capone, Domenico
Savastano, Silvia
author_facet Tarantino, Giovanni
Finelli, Carmine
Scopacasa, Franco
Pasanisi, Fabrizio
Contaldo, Franco
Capone, Domenico
Savastano, Silvia
author_sort Tarantino, Giovanni
collection PubMed
description The present study shows low circulating levels of SIRT4 in obese patients with nonalcoholic fatty liver disease mirroring its reduced mitochondrial expression in an attempt to increase the fat oxidative capacity and then the mitochondrial function in liver and in muscle. SIRT4 modulates the metabolism of free fatty acids reducing their high circulating levels but, unfortunately, increasing ROS production. Great concentration of free fatty acids, released by adipose tissue, coupled with oxidative stress, directly results in endothelial dysfunction, early atherosclerosis, and coronary artery disease risk factor.
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spelling pubmed-40866232014-07-20 Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes Tarantino, Giovanni Finelli, Carmine Scopacasa, Franco Pasanisi, Fabrizio Contaldo, Franco Capone, Domenico Savastano, Silvia Oxid Med Cell Longev Research Article The present study shows low circulating levels of SIRT4 in obese patients with nonalcoholic fatty liver disease mirroring its reduced mitochondrial expression in an attempt to increase the fat oxidative capacity and then the mitochondrial function in liver and in muscle. SIRT4 modulates the metabolism of free fatty acids reducing their high circulating levels but, unfortunately, increasing ROS production. Great concentration of free fatty acids, released by adipose tissue, coupled with oxidative stress, directly results in endothelial dysfunction, early atherosclerosis, and coronary artery disease risk factor. Hindawi Publishing Corporation 2014 2014-06-17 /pmc/articles/PMC4086623/ /pubmed/25045415 http://dx.doi.org/10.1155/2014/920676 Text en Copyright © 2014 Giovanni Tarantino et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tarantino, Giovanni
Finelli, Carmine
Scopacasa, Franco
Pasanisi, Fabrizio
Contaldo, Franco
Capone, Domenico
Savastano, Silvia
Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes
title Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes
title_full Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes
title_fullStr Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes
title_full_unstemmed Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes
title_short Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes
title_sort circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from nafld, with normal or slightly increased liver enzymes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086623/
https://www.ncbi.nlm.nih.gov/pubmed/25045415
http://dx.doi.org/10.1155/2014/920676
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