Stochasticity of Intranuclear Biochemical Reaction Processes Controls the Final Decision of Cell Fate Associated with DNA Damage

A massive integrative mathematical model of DNA double-strand break (DSB) generation, DSB repair system, p53 signaling network, and apoptosis induction pathway was constructed to explore the dominant factors of unknown criteria of cell fate decision. In the proposed model, intranuclear reactions wer...

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Detalles Bibliográficos
Autores principales: Iwamoto, Kazunari, Hamada, Hiroyuki, Eguchi, Yukihiro, Okamoto, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086823/
https://www.ncbi.nlm.nih.gov/pubmed/25003668
http://dx.doi.org/10.1371/journal.pone.0101333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086823/
https://www.ncbi.nlm.nih.gov/pubmed/25003668
http://dx.doi.org/10.1371/journal.pone.0101333

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