Phosphorylation Status of Thymidine Kinase 1 Following Antiproliferative Drug Treatment Mediates 3′-Deoxy-3′-[(18)F]-Fluorothymidine Cellular Retention

BACKGROUND: 3′-Deoxy-3′-[(18)F]-fluorothymidine ([(18)F]FLT) is being investigated as a Positron Emission Tomography (PET) proliferation biomarker. The mechanism of cellular [(18)F]FLT retention has been assigned primarily to alteration of the strict transcriptionally regulated S-phase expression of...

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Detalles Bibliográficos
Autores principales: Sala, Roberta, Nguyen, Quang-Dé, Patel, Chirag B. K., Mann, David, Steinke, Joachim H. G., Vilar, Ramon, Aboagye, Eric O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086825/
https://www.ncbi.nlm.nih.gov/pubmed/25003822
http://dx.doi.org/10.1371/journal.pone.0101366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086825/
https://www.ncbi.nlm.nih.gov/pubmed/25003822
http://dx.doi.org/10.1371/journal.pone.0101366

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