Inhibition Mechanism of the Intracellular Transporter Ca(2+)-Pump from Sarco-Endoplasmic Reticulum by the Antitumor Agent Dimethyl-Celecoxib

Dimethyl-celecoxib is a celecoxib analog that lacks the capacity as cyclo-oxygenase-2 inhibitor and therefore the life-threatening effects but retains the antineoplastic properties. The action mechanism at the molecular level is unclear. Our in vitro assays using a sarcoplasmic reticulum preparation...

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Detalles Bibliográficos
Autores principales: Coca, Ramón, Soler, Fernando, Cortés-Castell, Ernesto, Gil-Guillén, Vicente, Fernández-Belda, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086972/
https://www.ncbi.nlm.nih.gov/pubmed/25003576
http://dx.doi.org/10.1371/journal.pone.0102083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086972/
https://www.ncbi.nlm.nih.gov/pubmed/25003576
http://dx.doi.org/10.1371/journal.pone.0102083

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