Generation of muscular dystrophy model rats with a CRISPR/Cas system

Duchenne muscular dystrophy (DMD) is an X-linked lethal muscle disorder caused by mutations in the Dmd gene encoding Dystrophin12. DMD model animals, such as mdx mice and canine X-linked muscular dystrophy dogs, have been widely utilized in the development of a treatment for DMD3. Here, we demonstra...

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Detalles Bibliográficos
Autores principales: Nakamura, Katsuyuki, Fujii, Wataru, Tsuboi, Masaya, Tanihata, Jun, Teramoto, Naomi, Takeuchi, Shiho, Naito, Kunihiko, Yamanouchi, Keitaro, Nishihara, Masugi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088098/
https://www.ncbi.nlm.nih.gov/pubmed/25005781
http://dx.doi.org/10.1038/srep05635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088098/
https://www.ncbi.nlm.nih.gov/pubmed/25005781
http://dx.doi.org/10.1038/srep05635

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