Comparison of two endogenous biomarkers of CYP3A4 activity in a drug–drug interaction study between midostaurin and rifampicin

PURPOSE: Midostaurin, a multitargeted tyrosine kinase inhibitor, is primarily metabolized by CYP3A4. This midostaurin drug–drug interaction study assessed the dynamic response and clinical usefulness of urinary 6β-hydroxycortisol to cortisol ratio (6βCR) and plasma 4β-hydroxycholesterol (4βHC) for m...

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Detalles Bibliográficos
Autores principales: Dutreix, Catherine, Lorenzo, Sebastien, Wang, Yanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Clinical Trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088993/
https://www.ncbi.nlm.nih.gov/pubmed/24839948
http://dx.doi.org/10.1007/s00228-014-1675-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088993/
https://www.ncbi.nlm.nih.gov/pubmed/24839948
http://dx.doi.org/10.1007/s00228-014-1675-0

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