Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions

The cytosolic tripartite NLR receptors serve as important signalling platforms in innate immunity. While the C-terminal domains act as sensor and activation modules, the N-terminal death-like domain, e.g. the CARD or pyrin domain, is thought to recruit downstream effector molecules by homotypic inte...

Descripción completa

Detalles Bibliográficos
Autores principales: Eibl, Clarissa, Hessenberger, Manuel, Wenger, Julia, Brandstetter, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089490/
https://www.ncbi.nlm.nih.gov/pubmed/25004977
http://dx.doi.org/10.1107/S1399004714010311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089490/
https://www.ncbi.nlm.nih.gov/pubmed/25004977
http://dx.doi.org/10.1107/S1399004714010311

Ejemplares similares