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Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions
The cytosolic tripartite NLR receptors serve as important signalling platforms in innate immunity. While the C-terminal domains act as sensor and activation modules, the N-terminal death-like domain, e.g. the CARD or pyrin domain, is thought to recruit downstream effector molecules by homotypic inte...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089490/ https://www.ncbi.nlm.nih.gov/pubmed/25004977 http://dx.doi.org/10.1107/S1399004714010311 |