Pharmacogenetics of tacrolimus: ready for clinical translation?

Tacrolimus (Tac) exhibits an interindividual pharmacokinetic variability that affects the dose required to reach the target concentration in blood. Tac is metabolized by two enzymes of the cytochrome P450 family, CYP3A5 and CYP3A4. The effect of the CYP3A5 genotype on Tac bioavailability has been de...

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Detalles Bibliográficos
Autores principales: Coto, Eliecer, Tavira, Beatriz, Suárez-Álvarez, Beatriz, López-Larrea, Carlos, Díaz-Corte, Carmen, Ortega, Francisco, Álvarez, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Meeting Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089617/
https://www.ncbi.nlm.nih.gov/pubmed/25028625
http://dx.doi.org/10.1038/kisup.2011.14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089617/
https://www.ncbi.nlm.nih.gov/pubmed/25028625
http://dx.doi.org/10.1038/kisup.2011.14

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