Safety and Tolerability of Conserved Region Vaccines Vectored by Plasmid DNA, Simian Adenovirus and Modified Vaccinia Virus Ankara Administered to Human Immunodeficiency Virus Type 1-Uninfected Adults in a Randomized, Single-Blind Phase I Trial

TRIAL DESIGN: HIV-1 vaccine development has advanced slowly due to viral antigenic diversity, poor immunogenicity and recently, safety concerns associated with human adenovirus serotype-5 vectors. To tackle HIV-1 variation, we designed a unique T-cell immunogen HIVconsv from functionally conserved r...

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Detalles Bibliográficos
Autores principales: Hayton, Emma-Jo, Rose, Annie, Ibrahimsa, Umar, Del Sorbo, Mariarosaria, Capone, Stefania, Crook, Alison, Black, Antony P., Dorrell, Lucy, Hanke, Tomáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090156/
https://www.ncbi.nlm.nih.gov/pubmed/25007091
http://dx.doi.org/10.1371/journal.pone.0101591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090156/
https://www.ncbi.nlm.nih.gov/pubmed/25007091
http://dx.doi.org/10.1371/journal.pone.0101591

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