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Safety and Tolerability of Conserved Region Vaccines Vectored by Plasmid DNA, Simian Adenovirus and Modified Vaccinia Virus Ankara Administered to Human Immunodeficiency Virus Type 1-Uninfected Adults in a Randomized, Single-Blind Phase I Trial
TRIAL DESIGN: HIV-1 vaccine development has advanced slowly due to viral antigenic diversity, poor immunogenicity and recently, safety concerns associated with human adenovirus serotype-5 vectors. To tackle HIV-1 variation, we designed a unique T-cell immunogen HIVconsv from functionally conserved r...
Autores principales: | Hayton, Emma-Jo, Rose, Annie, Ibrahimsa, Umar, Del Sorbo, Mariarosaria, Capone, Stefania, Crook, Alison, Black, Antony P., Dorrell, Lucy, Hanke, Tomáš |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090156/ https://www.ncbi.nlm.nih.gov/pubmed/25007091 http://dx.doi.org/10.1371/journal.pone.0101591 |
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