The Capacity of Red Blood Cells to Reduce Nitrite Determines Nitric Oxide Generation under Hypoxic Conditions

Nitric oxide (NO) is a key regulator of vascular tone. Endothelial nitric oxide synthase (eNOS) is responsible for NO generation under normoxic conditions. Under hypoxia however, eNOS is inactive and red blood cells (RBC) provide an alternative NO generation pathway from nitrite to regulate hypoxic...

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Detalles Bibliográficos
Autores principales: Fens, Marcel H., Larkin, Sandra K., Oronsky, Bryan, Scicinski, Jan, Morris, Claudia R., Kuypers, Frans A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090171/
https://www.ncbi.nlm.nih.gov/pubmed/25007272
http://dx.doi.org/10.1371/journal.pone.0101626

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