Non-Circadian Expression Masking Clock-Driven Weak Transcription Rhythms in U2OS Cells

U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate with detectable rhythmic transcript levels. L...

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Detalles Bibliográficos
Autores principales: Hoffmann, Julia, Symul, Laura, Shostak, Anton, Fischer, Tamás, Naef, Felix, Brunner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090172/
https://www.ncbi.nlm.nih.gov/pubmed/25007071
http://dx.doi.org/10.1371/journal.pone.0102238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090172/
https://www.ncbi.nlm.nih.gov/pubmed/25007071
http://dx.doi.org/10.1371/journal.pone.0102238

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