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Non-Circadian Expression Masking Clock-Driven Weak Transcription Rhythms in U2OS Cells
U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate with detectable rhythmic transcript levels. L...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090172/ https://www.ncbi.nlm.nih.gov/pubmed/25007071 http://dx.doi.org/10.1371/journal.pone.0102238 |