Tandem Repeats and G-Rich Sequences Are Enriched at Human CNV Breakpoints

Chromosome breakage in germline and somatic genomes gives rise to copy number variation (CNV) responsible for genomic disorders and tumorigenesis. DNA sequence is known to play an important role in breakage at chromosome fragile sites; however, the sequences susceptible to double-strand breaks (DSBs...

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Detalles Bibliográficos
Autores principales: Bose, Promita, Hermetz, Karen E., Conneely, Karen N., Rudd, M. Katharine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090240/
https://www.ncbi.nlm.nih.gov/pubmed/24983241
http://dx.doi.org/10.1371/journal.pone.0101607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090240/
https://www.ncbi.nlm.nih.gov/pubmed/24983241
http://dx.doi.org/10.1371/journal.pone.0101607

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