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Tandem Repeats and G-Rich Sequences Are Enriched at Human CNV Breakpoints
Chromosome breakage in germline and somatic genomes gives rise to copy number variation (CNV) responsible for genomic disorders and tumorigenesis. DNA sequence is known to play an important role in breakage at chromosome fragile sites; however, the sequences susceptible to double-strand breaks (DSBs...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090240/ https://www.ncbi.nlm.nih.gov/pubmed/24983241 http://dx.doi.org/10.1371/journal.pone.0101607 |