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NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review

The protooncogene PCPH was recently identified as being the ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5). This protooncogene is converted into an oncogene by a single base pair deletion, resulting in frame change and producing a premature stop codon, leading to a mutated protein (mt-PCP...

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Autores principales: Bracco, Paula Andreghetto, Bertoni, Ana Paula Santin, Wink, Márcia Rosângela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090452/
https://www.ncbi.nlm.nih.gov/pubmed/25045656
http://dx.doi.org/10.1155/2014/123010
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author Bracco, Paula Andreghetto
Bertoni, Ana Paula Santin
Wink, Márcia Rosângela
author_facet Bracco, Paula Andreghetto
Bertoni, Ana Paula Santin
Wink, Márcia Rosângela
author_sort Bracco, Paula Andreghetto
collection PubMed
description The protooncogene PCPH was recently identified as being the ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5). This protooncogene is converted into an oncogene by a single base pair deletion, resulting in frame change and producing a premature stop codon, leading to a mutated protein (mt-PCPH) with only 27 kDa, which is much smaller than the original 47 kDa protein. Overexpression of the PCPH as well as the mutated PCPH increases the cellular resistance to stress and apoptosis. This is intriguing considering that the active form, that is, the oncogene, is the mutated PCPH. Several studies analyzed the expression of NTPDase5/mt-PCPH in a wide range of tumor cells and evaluated its role and mechanisms in cancer and other pathogenic processes. The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets.
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spelling pubmed-40904522014-07-20 NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review Bracco, Paula Andreghetto Bertoni, Ana Paula Santin Wink, Márcia Rosângela Biomed Res Int Review Article The protooncogene PCPH was recently identified as being the ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5). This protooncogene is converted into an oncogene by a single base pair deletion, resulting in frame change and producing a premature stop codon, leading to a mutated protein (mt-PCPH) with only 27 kDa, which is much smaller than the original 47 kDa protein. Overexpression of the PCPH as well as the mutated PCPH increases the cellular resistance to stress and apoptosis. This is intriguing considering that the active form, that is, the oncogene, is the mutated PCPH. Several studies analyzed the expression of NTPDase5/mt-PCPH in a wide range of tumor cells and evaluated its role and mechanisms in cancer and other pathogenic processes. The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets. Hindawi Publishing Corporation 2014 2014-06-23 /pmc/articles/PMC4090452/ /pubmed/25045656 http://dx.doi.org/10.1155/2014/123010 Text en Copyright © 2014 Paula Andreghetto Bracco et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bracco, Paula Andreghetto
Bertoni, Ana Paula Santin
Wink, Márcia Rosângela
NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review
title NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review
title_full NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review
title_fullStr NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review
title_full_unstemmed NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review
title_short NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review
title_sort ntpdase5/pcph as a new target in highly aggressive tumors: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090452/
https://www.ncbi.nlm.nih.gov/pubmed/25045656
http://dx.doi.org/10.1155/2014/123010
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