Cargando…
NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review
The protooncogene PCPH was recently identified as being the ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5). This protooncogene is converted into an oncogene by a single base pair deletion, resulting in frame change and producing a premature stop codon, leading to a mutated protein (mt-PCP...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090452/ https://www.ncbi.nlm.nih.gov/pubmed/25045656 http://dx.doi.org/10.1155/2014/123010 |
_version_ | 1782480635217051648 |
---|---|
author | Bracco, Paula Andreghetto Bertoni, Ana Paula Santin Wink, Márcia Rosângela |
author_facet | Bracco, Paula Andreghetto Bertoni, Ana Paula Santin Wink, Márcia Rosângela |
author_sort | Bracco, Paula Andreghetto |
collection | PubMed |
description | The protooncogene PCPH was recently identified as being the ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5). This protooncogene is converted into an oncogene by a single base pair deletion, resulting in frame change and producing a premature stop codon, leading to a mutated protein (mt-PCPH) with only 27 kDa, which is much smaller than the original 47 kDa protein. Overexpression of the PCPH as well as the mutated PCPH increases the cellular resistance to stress and apoptosis. This is intriguing considering that the active form, that is, the oncogene, is the mutated PCPH. Several studies analyzed the expression of NTPDase5/mt-PCPH in a wide range of tumor cells and evaluated its role and mechanisms in cancer and other pathogenic processes. The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets. |
format | Online Article Text |
id | pubmed-4090452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40904522014-07-20 NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review Bracco, Paula Andreghetto Bertoni, Ana Paula Santin Wink, Márcia Rosângela Biomed Res Int Review Article The protooncogene PCPH was recently identified as being the ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5). This protooncogene is converted into an oncogene by a single base pair deletion, resulting in frame change and producing a premature stop codon, leading to a mutated protein (mt-PCPH) with only 27 kDa, which is much smaller than the original 47 kDa protein. Overexpression of the PCPH as well as the mutated PCPH increases the cellular resistance to stress and apoptosis. This is intriguing considering that the active form, that is, the oncogene, is the mutated PCPH. Several studies analyzed the expression of NTPDase5/mt-PCPH in a wide range of tumor cells and evaluated its role and mechanisms in cancer and other pathogenic processes. The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets. Hindawi Publishing Corporation 2014 2014-06-23 /pmc/articles/PMC4090452/ /pubmed/25045656 http://dx.doi.org/10.1155/2014/123010 Text en Copyright © 2014 Paula Andreghetto Bracco et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bracco, Paula Andreghetto Bertoni, Ana Paula Santin Wink, Márcia Rosângela NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review |
title | NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review |
title_full | NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review |
title_fullStr | NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review |
title_full_unstemmed | NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review |
title_short | NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review |
title_sort | ntpdase5/pcph as a new target in highly aggressive tumors: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090452/ https://www.ncbi.nlm.nih.gov/pubmed/25045656 http://dx.doi.org/10.1155/2014/123010 |
work_keys_str_mv | AT braccopaulaandreghetto ntpdase5pcphasanewtargetinhighlyaggressivetumorsasystematicreview AT bertonianapaulasantin ntpdase5pcphasanewtargetinhighlyaggressivetumorsasystematicreview AT winkmarciarosangela ntpdase5pcphasanewtargetinhighlyaggressivetumorsasystematicreview |