Metadynamics Simulation Study on the Conformational Transformation of HhaI Methyltransferase: An Induced-Fit Base-Flipping Hypothesis

DNA methyltransferases play crucial roles in establishing and maintenance of DNA methylation, which is an important epigenetic mark. Flipping the target cytosine out of the DNA helical stack and into the active site of protein provides DNA methyltransferases with an opportunity to access and modify...

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Detalles Bibliográficos
Autores principales: Jin, Lu, Ye, Fei, Zhao, Dan, Chen, Shijie, Zhu, Kongkai, Zheng, Mingyue, Jiang, Ren-Wang, Jiang, Hualiang, Luo, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090504/
https://www.ncbi.nlm.nih.gov/pubmed/25045662
http://dx.doi.org/10.1155/2014/304563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090504/
https://www.ncbi.nlm.nih.gov/pubmed/25045662
http://dx.doi.org/10.1155/2014/304563

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