Cargando…

Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer's Disease Transgenic Mouse Model

We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning...

Descripción completa

Detalles Bibliográficos
Autores principales: Subash, Selvaraju, Essa, Musthafa Mohamed, Al-Asmi, Abdullah, Al-Adawi, Samir, Vaishnav, Ragini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090508/
https://www.ncbi.nlm.nih.gov/pubmed/25050360
http://dx.doi.org/10.1155/2014/546357
_version_ 1782480652729319424
author Subash, Selvaraju
Essa, Musthafa Mohamed
Al-Asmi, Abdullah
Al-Adawi, Samir
Vaishnav, Ragini
author_facet Subash, Selvaraju
Essa, Musthafa Mohamed
Al-Asmi, Abdullah
Al-Adawi, Samir
Vaishnav, Ragini
author_sort Subash, Selvaraju
collection PubMed
description We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on control diet without figs showed significant impairment in spatial learning ability compared to the wild-type mice on same diet and figs fed Tg mice as well. Significant increase in oxidative stress and reduced antioxidant status were observed in AD Tg mice. 4% figs treated AD Tg mice significantly attenuated oxidative damage, as evident by decreased lipid peroxidation and protein carbonyls and restoration of antioxidant status. Altered activities of membrane bound enzymes (Na(+) K(+) ATPase and acetylcholinesterase (AChE)) in AD Tg mice brain regions and was restored by figs treatment. Further, figs supplementation might be able to decrease the plasma levels of Aβ (1–40, 1–42) significantly in Tg mice suggesting a putative delay in the formation of plaques, which might be due to the presence of high natural antioxidants in figs. But this study warrants further extensive investigation to find a novel lead for a therapeutic target for AD from figs.
format Online
Article
Text
id pubmed-4090508
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40905082014-07-21 Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer's Disease Transgenic Mouse Model Subash, Selvaraju Essa, Musthafa Mohamed Al-Asmi, Abdullah Al-Adawi, Samir Vaishnav, Ragini Biomed Res Int Research Article We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on control diet without figs showed significant impairment in spatial learning ability compared to the wild-type mice on same diet and figs fed Tg mice as well. Significant increase in oxidative stress and reduced antioxidant status were observed in AD Tg mice. 4% figs treated AD Tg mice significantly attenuated oxidative damage, as evident by decreased lipid peroxidation and protein carbonyls and restoration of antioxidant status. Altered activities of membrane bound enzymes (Na(+) K(+) ATPase and acetylcholinesterase (AChE)) in AD Tg mice brain regions and was restored by figs treatment. Further, figs supplementation might be able to decrease the plasma levels of Aβ (1–40, 1–42) significantly in Tg mice suggesting a putative delay in the formation of plaques, which might be due to the presence of high natural antioxidants in figs. But this study warrants further extensive investigation to find a novel lead for a therapeutic target for AD from figs. Hindawi Publishing Corporation 2014 2014-06-19 /pmc/articles/PMC4090508/ /pubmed/25050360 http://dx.doi.org/10.1155/2014/546357 Text en Copyright © 2014 Selvaraju Subash et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Subash, Selvaraju
Essa, Musthafa Mohamed
Al-Asmi, Abdullah
Al-Adawi, Samir
Vaishnav, Ragini
Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer's Disease Transgenic Mouse Model
title Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer's Disease Transgenic Mouse Model
title_full Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer's Disease Transgenic Mouse Model
title_fullStr Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer's Disease Transgenic Mouse Model
title_full_unstemmed Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer's Disease Transgenic Mouse Model
title_short Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer's Disease Transgenic Mouse Model
title_sort chronic dietary supplementation of 4% figs on the modification of oxidative stress in alzheimer's disease transgenic mouse model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090508/
https://www.ncbi.nlm.nih.gov/pubmed/25050360
http://dx.doi.org/10.1155/2014/546357
work_keys_str_mv AT subashselvaraju chronicdietarysupplementationof4figsonthemodificationofoxidativestressinalzheimersdiseasetransgenicmousemodel
AT essamusthafamohamed chronicdietarysupplementationof4figsonthemodificationofoxidativestressinalzheimersdiseasetransgenicmousemodel
AT alasmiabdullah chronicdietarysupplementationof4figsonthemodificationofoxidativestressinalzheimersdiseasetransgenicmousemodel
AT aladawisamir chronicdietarysupplementationof4figsonthemodificationofoxidativestressinalzheimersdiseasetransgenicmousemodel
AT vaishnavragini chronicdietarysupplementationof4figsonthemodificationofoxidativestressinalzheimersdiseasetransgenicmousemodel