The cytotoxicity of (–)-lomaiviticin A arises from induction of double-strand breaks in DNA

The metabolite (–)-lomaiviticin A, which contains two diazotetrahydrobenzo[b]fluorene (diazofluorene) functional groups, inhibits the growth of cultured human cancer cells at nanomolar–picomolar concentrations; however, the mechanism responsible for the potent cytotoxicity of this natural product is...

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Detalles Bibliográficos
Autores principales: Colis, Laureen C., Woo, Christina M., Hegan, Denise C., Li, Zhenwu, Glazer, Peter M., Herzon, Seth B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090708/
https://www.ncbi.nlm.nih.gov/pubmed/24848236
http://dx.doi.org/10.1038/nchem.1944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090708/
https://www.ncbi.nlm.nih.gov/pubmed/24848236
http://dx.doi.org/10.1038/nchem.1944

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