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The cytotoxicity of (–)-lomaiviticin A arises from induction of double-strand breaks in DNA
The metabolite (–)-lomaiviticin A, which contains two diazotetrahydrobenzo[b]fluorene (diazofluorene) functional groups, inhibits the growth of cultured human cancer cells at nanomolar–picomolar concentrations; however, the mechanism responsible for the potent cytotoxicity of this natural product is...
Autores principales: | Colis, Laureen C., Woo, Christina M., Hegan, Denise C., Li, Zhenwu, Glazer, Peter M., Herzon, Seth B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090708/ https://www.ncbi.nlm.nih.gov/pubmed/24848236 http://dx.doi.org/10.1038/nchem.1944 |
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