Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Chronic inflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the transcription factor NF-κB induces premature ageing in mice. We also show that these mice have reduced regeneration in...

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Detalles Bibliográficos
Autores principales: Jurk, Diana, Wilson, Caroline, Passos, João F., Oakley, Fiona, Correia-Melo, Clara, Greaves, Laura, Saretzki, Gabriele, Fox, Chris, Lawless, Conor, Anderson, Rhys, Hewitt, Graeme, Pender, Sylvia LF, Fullard, Nicola, Nelson, Glyn, Mann, Jelena, van de Sluis, Bart, Mann, Derek A., von Zglinicki, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090717/
https://www.ncbi.nlm.nih.gov/pubmed/24960204
http://dx.doi.org/10.1038/ncomms5172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090717/
https://www.ncbi.nlm.nih.gov/pubmed/24960204
http://dx.doi.org/10.1038/ncomms5172

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