Phosphorylation of NBR1 by GSK3 modulates protein aggregation

The autophagy receptor NBR1 (neighbor of BRCA1 gene 1) binds UB/ubiquitin and the autophagosome-conjugated MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3) proteins, thereby ensuring ubiquitinated protein degradation. Numerous neurodegenerative and neuromuscular diseases are associated w...

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Detalles Bibliográficos
Autores principales: Nicot, Anne-Sophie, Lo Verso, Francesca, Ratti, Francesca, Pilot-Storck, Fanny, Streichenberger, Nathalie, Sandri, Marco, Schaeffer, Laurent, Goillot, Evelyne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Basic Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091167/
https://www.ncbi.nlm.nih.gov/pubmed/24879152
http://dx.doi.org/10.4161/auto.28479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091167/
https://www.ncbi.nlm.nih.gov/pubmed/24879152
http://dx.doi.org/10.4161/auto.28479

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