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The challenge in translating basic research discoveries to treatment of Huntington disease

Huntington disease is a rare neurodegenerative disease resulting from insertion and/or expansion of a polyglutamine repeats close to the N-terminal of the huntingtin protein. Although unequivocal genetic tests have been available for about 20 years, current pharmacological treatments do not prevent...

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Detalles Bibliográficos
Autores principales: Mochly-Rosen, Daria, Disatnik, Marie-Helene, Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091548/
https://www.ncbi.nlm.nih.gov/pubmed/25054095
http://dx.doi.org/10.4161/rdis.28637