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SETX sumoylation: A link between DNA damage and RNA surveillance disrupted in AOA2
Senataxin (SETX) is a putative RNA:DNA helicase that is mutated in two distinct juvenile neurological disorders, AOA2 and ALS4. SETX is involved in the response to oxidative stress and is suggested to resolve R loops formed at transcription termination sites or at sites of collisions between the tra...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091563/ https://www.ncbi.nlm.nih.gov/pubmed/25054092 http://dx.doi.org/10.4161/rdis.27744 |