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A Drosophila screen identifies neurofibromatosis-1 genetic modifiers involved in systemic and synaptic growth
Neurofibromatosis type 1 (NF1) is caused by loss of a negative regulator of Ras oncoproteins. Unknown genetic modifiers have been implicated in NF1’s characteristic variability. Drosophila melanogaster dNf1 phenotypes include cognitive deficits and reduced growth, both of which resemble human sympto...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091572/ https://www.ncbi.nlm.nih.gov/pubmed/25054093 http://dx.doi.org/10.4161/rdis.28341 |