Role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments

We identify novel mechanisms whereby chemoresistance enables cancer stem cells to create pro-inflammatory tumor microenvironments. Chemoresistant cancer stem cells promote M2 macrophage differentiation through interferon-regulatory factor-5 (IRF5)- and macrophage-colony stimulating factor (M-CSF)-de...

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Detalles Bibliográficos
Autor principal: Jinushi, Masahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091611/
https://www.ncbi.nlm.nih.gov/pubmed/25057449
http://dx.doi.org/10.4161/onci.28862
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author Jinushi, Masahisa
author_facet Jinushi, Masahisa
author_sort Jinushi, Masahisa
collection PubMed
description We identify novel mechanisms whereby chemoresistance enables cancer stem cells to create pro-inflammatory tumor microenvironments. Chemoresistant cancer stem cells promote M2 macrophage differentiation through interferon-regulatory factor-5 (IRF5)- and macrophage-colony stimulating factor (M-CSF)-dependent mechanisms and produce various other cell-signaling factors that together fuel inflammation-driven carcinogenesis. These findings clarify a molecular pathway linking cancer “stemness” and pro-tumor inflammation in an immunosuppressive niche.
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spelling pubmed-40916112014-07-23 Role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments Jinushi, Masahisa Oncoimmunology Author's View We identify novel mechanisms whereby chemoresistance enables cancer stem cells to create pro-inflammatory tumor microenvironments. Chemoresistant cancer stem cells promote M2 macrophage differentiation through interferon-regulatory factor-5 (IRF5)- and macrophage-colony stimulating factor (M-CSF)-dependent mechanisms and produce various other cell-signaling factors that together fuel inflammation-driven carcinogenesis. These findings clarify a molecular pathway linking cancer “stemness” and pro-tumor inflammation in an immunosuppressive niche. Landes Bioscience 2014-05-15 /pmc/articles/PMC4091611/ /pubmed/25057449 http://dx.doi.org/10.4161/onci.28862 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Jinushi, Masahisa
Role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments
title Role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments
title_full Role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments
title_fullStr Role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments
title_full_unstemmed Role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments
title_short Role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments
title_sort role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091611/
https://www.ncbi.nlm.nih.gov/pubmed/25057449
http://dx.doi.org/10.4161/onci.28862
work_keys_str_mv AT jinushimasahisa roleofcancerstemcellassociatedinflammationincreatingproinflammatorytumorigenicmicroenvironments

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