Hypersensitivity of Primordial Germ Cells to Compromised Replication-Associated DNA Repair Involves ATM-p53-p21 Signaling

Genome maintenance in germ cells is critical for fertility and the stable propagation of species. While mechanisms of meiotic DNA repair and chromosome behavior are well-characterized, the same is not true for primordial germ cells (PGCs), which arise and propagate during very early stages of mammal...

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Detalles Bibliográficos
Autores principales: Luo, Yunhai, Hartford, Suzanne A., Zeng, Ruizhu, Southard, Teresa L., Shima, Naoko, Schimenti, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091704/
https://www.ncbi.nlm.nih.gov/pubmed/25010009
http://dx.doi.org/10.1371/journal.pgen.1004471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091704/
https://www.ncbi.nlm.nih.gov/pubmed/25010009
http://dx.doi.org/10.1371/journal.pgen.1004471

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