Brg1 Loss Attenuates Aberrant Wnt-Signalling and Prevents Wnt-Dependent Tumourigenesis in the Murine Small Intestine

Tumourigenesis within the intestine is potently driven by deregulation of the Wnt pathway, a process epigenetically regulated by the chromatin remodelling factor Brg1. We aimed to investigate this interdependency in an in vivo setting and assess the viability of Brg1 as a potential therapeutic targe...

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Detalles Bibliográficos
Autores principales: Holik, Aliaksei Z., Young, Madeleine, Krzystyniak, Joanna, Williams, Geraint T., Metzger, Daniel, Shorning, Boris Y., Clarke, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091792/
https://www.ncbi.nlm.nih.gov/pubmed/25010414
http://dx.doi.org/10.1371/journal.pgen.1004453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091792/
https://www.ncbi.nlm.nih.gov/pubmed/25010414
http://dx.doi.org/10.1371/journal.pgen.1004453

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