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Dynactin integrity depends upon direct binding of dynamitin to Arp1

Dynactin is a multiprotein complex that works with cytoplasmic dynein and other motors to support a wide range of cell functions. It serves as an adaptor that binds both dynein and cargoes and enhances single-motor processivity. The dynactin subunit dynamitin (also known as p50) is believed to be in...

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Detalles Bibliográficos
Autores principales: Cheong, Frances Ka Yan, Feng, Lijuan, Sarkeshik, Ali, Yates, John R., Schroer, Trina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091830/
https://www.ncbi.nlm.nih.gov/pubmed/24829381
http://dx.doi.org/10.1091/mbc.E14-03-0842