hBD-2 is downregulated in oral carcinoma cells by DNA hypermethylation, and increased expression of hBD-2 by DNA demethylation and gene transfection inhibits cell proliferation and invasion

Human β-defensin-2 (hBD-2) is a type of epithelial antimicrobial peptide. The expression level of hBD-2 mRNA is lower in oral carcinoma cells (OCCs) than in healthy oral epithelium. Yet, it is still unknown how hBD-2 expression is downregulated in OCCs. The present study investigated DNA hypermethyl...

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Detalles Bibliográficos
Autores principales: KAMINO, YOSHITAKA, KURASHIGE, YOSHIHITO, UEHARA, OSAMU, SATO, JUN, NISHIMURA, MICHIKO, YOSHIDA, KOKI, ARAKAWA, TOSHIYA, NAGAYASU, HIROKI, SAITOH, MASATO, ABIKO, YOSHIHIRO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091880/
https://www.ncbi.nlm.nih.gov/pubmed/24927104
http://dx.doi.org/10.3892/or.2014.3260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091880/
https://www.ncbi.nlm.nih.gov/pubmed/24927104
http://dx.doi.org/10.3892/or.2014.3260

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