Inhibition of Human Dyskerin as a New Approach to Target Ribosome Biogenesis

The product of the DKC1 gene, dyskerin, is required for both ribosome biogenesis and telomerase complex stabilization. Targeting these cellular processes has been explored for the development of drugs to selectively or preferentially kill cancer cells. Presently, intense research is conducted involv...

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Detalles Bibliográficos
Autores principales: Rocchi, Laura, Barbosa, Arménio J. M., Onofrillo, Carmine, Del Rio, Alberto, Montanaro, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092089/
https://www.ncbi.nlm.nih.gov/pubmed/25010840
http://dx.doi.org/10.1371/journal.pone.0101971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092089/
https://www.ncbi.nlm.nih.gov/pubmed/25010840
http://dx.doi.org/10.1371/journal.pone.0101971

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