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Investigation of a MMP-2 Activity-Dependent Anchoring Probe for Nuclear Imaging of Cancer
PURPOSE: Since matrix metalloproteinase-2 (MMP-2) is an important marker of tumor malignancy, we developed an original drug design strategy, MMP-2 activity dependent anchoring probes (MDAP), for use in MMP-2 activity imaging, and evaluated the usefulness of this probe in in vitro and in vivo experim...
Autores principales: | Temma, Takashi, Hanaoka, Hirofumi, Yonezawa, Aki, Kondo, Naoya, Sano, Kohei, Sakamoto, Takeharu, Seiki, Motoharu, Ono, Masahiro, Saji, Hideo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092090/ https://www.ncbi.nlm.nih.gov/pubmed/25010662 http://dx.doi.org/10.1371/journal.pone.0102180 |
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